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Hospital Warns of Possible Patient HIV Transmission
South Nassau Communities Hospital on Long Island is sending more than 4000 patients letters warning that they may have been exposed to the hepatitis virus and HIV through the multiple use of an insulin reservoir. Although officials think the risk of HIV transmission is very low, they are notifying possibly infected patients through an abundance of caution.
The post Hospital Warns of Possible Patient HIV Transmission appeared first on InsideSurgery Medical Information Blog.
Source: Inside Surgery - March 14, 2014 Category: Surgeons Authors: Editor Tags: Infectious Disease Medical News Wire hepatitis HIV insulin pen South Nassau Communities Hospital Source Type: blogs
Superior outcomes in HIV–positive kidney transplant patients compared with HCV–infected or HIV/HCV–coinfected recipients
Superior outcomes in HIV–positive kidney transplant patients compared with HCV–infected or HIV/HCV–coinfected recipients
Kidney International 88,
341 (August 2015). doi:10.1038/ki.2015.74
Authors: Deirdre Sawinski, Kimberly A Forde, Kevin Eddinger, Andrea B Troxel, Emily Blumberg, Pablo Tebas, Peter L Abt & Roy D Bloom
Source: Kidney International - July 31, 2015 Category: Urology & Nephrology Authors: Deirdre SawinskiKimberly A FordeKevin EddingerAndrea B TroxelEmily BlumbergPablo TebasPeter L AbtRoy D Bloom Tags: Hepatitis C (HCV) human immunodeficiency virus (HIV) kidney transplant outcomes Source Type: research
Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland,
Brandee L. Branche,
Lauren E. Howard,
Robert J. Hamilton,
William J. Aronson,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research
Screening strategies for the diagnosis of asymptomatic Leishmania infection in dialysis patients as a model for kidney transplant candidates.
Abstract
Despite being considered a tropical disease, visceral leishmaniasis (VL) caused by L. infantum is also endemic in the Mediterranean Europe and represents an increasing cause of morbidity and mortality in solid organ transplant (SOT) recipients. VL occurring in kidney transplant recipients is a severe event, often worsening the renal damage and leading to poor outcome. It is believed that most of VL cases in transplant recipients are caused by reactivation of a pre-existent, dormant leishmanial infection induced by the immunosuppressive drugs. Nevertheless, the prevalence of asymptomatic Leishmania infecti...
Source: Journal of Nephrology - January 29, 2020 Category: Urology & Nephrology Authors: Comai G, Mistral De Pascali A, Busutti M, Morini S, Ortalli M, Conte D, Re MC, La Manna G, Varani S Tags: J Nephrol Source Type: research
Leishmania infantum-chagasi activates SHP-1 and reduces NFAT5/TonEBP activity in the mouse kidney inner medulla.
Abstract
Visceral leishmaniasis patients have been reported to have a urine concentration defect. Concentration of urine by the renal inner medulla is essentially dependent on a transcription factor, NFAT5/TonEBP, because it activates expression of osmoprotective genes BGT1 and SMIT, and water channel aquaporin-2, all of which are imperative for concentrating urine. Leishmania parasites evade macrophage immune defenses by activating protein tyrosine phosphatases, among which SHP-1 is critical. We previously demonstrated that SHP-1 inhibits tonicity-dependent activation of NFAT5/TonEBP in HEK293 cells through scree...
Source: Am J Physiol Renal P... - July 2, 2014 Category: Urology & Nephrology Authors: Zhou X, Wang H, Koles NL, Zhang A, Aronson NE Tags: Am J Physiol Renal Physiol Source Type: research
Leishmania infantum-chagasi activates SHP-1 and reduces NFAT5/TonEBP activity in the mouse kidney inner medulla
Visceral leishmaniasis patients have been reported to have a urine concentration defect. Concentration of urine by the renal inner medulla is essentially dependent on a transcription factor, NFAT5/TonEBP, because it activates expression of osmoprotective genes betaine/glycine transporter 1 (BGT1) and sodium/myo-inositol transporter (SMIT), and water channel aquaporin-2, all of which are imperative for concentrating urine. Leishmania parasites evade macrophage immune defenses by activating protein tyrosine phosphatases, among which SHP-1 is critical. We previously demonstrated that SHP-1 inhibits tonicity-dependent activati...
Source: AJP: Renal Physiology - September 1, 2014 Category: Urology & Nephrology Authors: Zhou, X., Wang, H., Koles, N. L., Zhang, A., Aronson, N. E. Tags: ARTICLES Source Type: research
HIV compromises integrity of the podocyte actin cytoskeleton through downregulation of the vitamin D receptor
Alterations in the podocyte actin cytoskeleton have been implicated in the development of proteinuric kidney diseases. In the present study, we evaluated the effect of HIV on the podocyte actin cytoskeleton and the mechanism involved. We hypothesized that HIV may be compromising the actin cytoskeleton via downregulation of the vitamin D receptor (VDR) of conditionally immortalized differentiated human podocytes (CIDHPs). HIV-transduced podocytes (HIV/CIDHPs) not only displayed downregulation of VDR but also showed activation of the renin-angiotensin system (RAS) in the form of enhanced expression of renin and increased pro...
Source: AJP: Renal Physiology - June 1, 2013 Category: Urology & Nephrology Authors: Chandel, N., Sharma, B., Husain, M., Salhan, D., Singh, T., Rai, P., Mathieson, P. W., Saleem, M. A., Malhotra, A., Singhal, P. C. Tags: ARTICLES Source Type: research
A National Study of Outcomes among HIV-Infected Kidney Transplant Recipients
In conclusion, HIV-negative and HIV monoinfected kidney transplant recipients had similar GS and PS, whereas HIV/HCV coinfected recipients had worse outcomes. Although encouraging, these results suggest caution in transplanting coinfected patients.
Source: Journal of the American Society of Nephrology : JASN - August 31, 2015 Category: Urology & Nephrology Authors: Locke, J. E., Mehta, S., Reed, R. D., MacLennan, P., Massie, A., Nellore, A., Durand, C., Segev, D. L. Tags: Clinical Epidemiology Source Type: research
Continuous ambulatory peritoneal dialysis in patients with hiv and end-stage renal failure.
Conclusion: Although HIV-seropositive status of patients on CAPD did not adversely influence technique failure rates or patency at 1 year, uncontrolled HIV infection may be associated with increased relative risk of mortality and morbidity.
PMID: 27935535 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - December 12, 2016 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy
ConclusionsThe seminal HIV load was used to monitor risk for infertile HIV-infected patients on an assisted reproductive technology program. This can still be recommended for patients who recently (6 months) started ART, or those with a poor history of adherence to ART but may also be usefull for some patients during counselling. Residual HIV seminal shedding is probably linked to breaks in adherence to antiretroviral treatment but local genital factors cannot be ruled out.
Source: Basic and Clinical Andrology - September 8, 2017 Category: Urology & Nephrology Source Type: research
Kidney Disease in HIV: Moving beyond HIV-Associated Nephropathy
In developed countries, remarkable advances in antiretroviral therapy have transformed HIV infection into a chronic condition. As a result, HIV-associated nephropathy, the classic HIV-driven kidney lesion among individuals of African descent, has largely disappeared in these regions. However, HIV-positive blacks continue to have much higher rates of ESRD than HIV-positive whites, which could be attributed to the APOL1 renal risk variants. Additionally, HIV-positive individuals face adverse consequences beyond HIV itself, including traditional risk factors for CKD and nephrotoxic effects of antiretroviral therapy. Concerns ...
Source: Journal of the American Society of Nephrology : JASN - October 31, 2017 Category: Urology & Nephrology Authors: Jotwani, V., Atta, M. G., Estrella, M. M. Tags: Brief Reviews Source Type: research
Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy
ConclusionsThe seminal HIV load was used to monitor risk for infertile HIV-infected patients on an assisted reproductive technology program. This can still be recommended for patients who recently (6 months) started ART, or those with a poor history of adherence to ART but may also be usefull for some patients during counselling. Residual HIV seminal shedding is probably linked to breaks in adherence to antiretroviral treatment but local genital factors cannot be ruled out.
Source: Basic and Clinical Andrology - September 8, 2017 Category: Urology & Nephrology Source Type: research
Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men.
CONCLUSIONS: Among HIV+ men, higher urine albumin and α1m are associated with subsequent declines in kidney function, independent of eGFR.
PMID: 31553981 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - September 24, 2019 Category: Urology & Nephrology Authors: Ascher SB, Scherzer R, Estrella MM, Shlipak MG, Ng DK, Palella FJ, Witt MD, Ho K, Bennett MR, Parikh CR, Ix JH, Jotwani V Tags: Am J Nephrol Source Type: research
Prostate cancer presentation, treatment selection, and outcomes among men with HIV/AIDS: A clinical stage, race, and age-matched contemporary analysis.
CONCLUSIONS: While most HIV+ patients had a history of acquired immune deficiency syndrome; HIV was well controlled in the majority of patients at the time of CaP diagnosis. While oncologic outcomes were similar between HIV+ and HIV- men, significant differences in treatment selection were observed. Further research is necessary to understand differences in treatment election by HIV status and to define optimal CaP treatment selection in men with HIV.
PMID: 32843291 [PubMed - as supplied by publisher]
Source: Urologic Oncology - August 21, 2020 Category: Urology & Nephrology Authors: Ruden M, Olivares CH, Fakhoury MQ, Roston A, Vidal PP, Hollowell CMP, Psutka SP Tags: Urol Oncol Source Type: research
Regional and Racial Disparities in HIV-Related Kidney Disease
Contrib Nephrol. 2021 Aug 3;199:1-8. doi: 10.1159/000517702. Online ahead of print.ABSTRACTClinical Background and Epidemiology: Worldwide, an estimated 38 million people are living with HIV infection. The classic kidney disease of HIV infection, commonly known as HIV-associated nephropathy, is a collapsing form of focal segmental glomerulosclerosis that almost exclusively affects individuals of African descent with advanced HIV disease. People living with HIV are also at risk for immune-complex kidney diseases, antiretroviral nephrotoxicity, and kidney disease due to co-infections and comorbidities. Challenges: The burden...
Source: Contributions to Nephrology - August 3, 2021 Category: Urology & Nephrology Authors: Matthew Sinclair Christina M Wyatt Source Type: research
